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Viral hepatitis: early detection can head off later complications
Hepatitis means
'inflammation of the liver.' Hepatitis may be caused by viruses,
drugs and other causes. Hepatitis A, B and C are the most common
forms of viral hepatitis. Viral hepatitis can be a potentially fatal
disease, one that affects millions of Americans. But, hepatitis can
be a 'silent killer,' in that hepatitis infection may produce no
symptoms for years, even decades.
"During chronic infection, it is much more difficult to make a diagnosis.
Chronic means lasting longer than six months. Most patients with
chronic hepatitis B or C have no symptoms until they have very
advanced liver damage, so they remain symptom free for up to
decades. It's only when they start developing cirrhosis or liver
cancer that they start manifesting symptoms," says Anna Lok, M.D.,
professor of internal medicine and director of clinical hepatology
at the U-M Health System.
"On the other hand, hepatitis A is a transient, acute infection. It
doesn't progress to chronic infection, so its impact on morbidity,
mortality, as well as health care costs, is far less than with
hepatitis B and C," she explains. "Most people recover from
hepatitis A with supportive care only."
According to Lok, the Centers for Disease Prevention and Control
estimates that about 3 million Americans are chronically infected
with the hepatitis C virus, which is the most common hepatitis in
the United States. Hepatitis C is also the most frequent reason for
liver transplantation among adult patients. Roughly 1.25 million
Americans have chronic hepatitis B.
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Lok warns that individuals should know of the risk factors for acquiring viral
hepatitis and if they are concerned that they have any of those risk
factors they should talk to their health care providers, and
consider a simple blood test to determine if they are infected.
"It is so
much easier to diagnose early and treat early. Treatment in an early
stage, if successful, may prevent progression of the liver disease,
and knowing you have it also allows you to take necessary steps to
prevent transmission of the infection to others. People who already
know they are hepatitis B or C positive should seek further
evaluation even if they have no symptoms, because is very common for
people to not have symptoms until the liver damage is very severe,"
says Lok.
Not all
patients with chronic hepatitis B or C require specific medical
treatment but some may benefit from active intervention. If you know
that you are infected, see your physician to determine the severity
of liver damage and if you may benefit from treatment.
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It is important to note that alcohol accelerates the disease's progress in
people with chronic hepatitis.
"In patients with cirrhosis, we recommend complete abstinence. Even small amounts
of drinking can accelerate disease progression," Lok says.
Prevention is also an important tool for preventing the spread of these
infections. There are specific preventions people can take to
protect others, such as avoiding sharing needles or household
articles (such as razors and toothbrushes) that may be contaminated
with blood, and practicing safe sex. There are vaccines for
hepatitis A and B. As hepatitis C is spread only through
blood-to-blood contact, health care workers, law enforcement
personnel and others at risk for exposure are trained in the
precautions they can take.
Here are
the facts:
Hepatitis A: This liver infection is largely spread through contaminated food or water. It
causes acute infection only, meaning there is a single transient
episode of the disease. The virus is harbored in the stools of
people who are infected and can move to other people's food via
unwashed hands. Problems with municipal sewage systems can also
release infected sewage into the water supply.
The older an
infected person is, the more likely the acute attack will be severe.
Mortality is between two and three percent if the patient's age is
over 50, but mortality is nearly zero for younger people. People can
have it and not know it because the symptoms aren't always severe.
- Hepatitis A symptoms: Fever, fatigue, loss of appetite, nausea, vomiting and
jaundice.
- Diagnosis: Blood test
- People at risk: People traveling to underdeveloped countries; the military;
those working in day care where there are a lot of incontinent
babies in diapers
- How it spreads: Usually spread by eating food or drinking water that has
been contaminated by the virus. The virus can be found in the
stools of people who have hepatitis A, so poor hand-washing
techniques by someone infected with the virus, or sewage spills
into the community water system are common ways for the virus to
spread.
-
Prevention: For people at risk: vaccination. To minimize spread to
food and water: good hand washing techniques among people with
hepatitis A; enforcing sewage laws and keeping sewage treatment
plants in good working condition
- Treatment:
Most people improve on their own, over a few weeks or months.
Hepatitis A does not progress to chronic infection and will not
cause cirrhosis.
Hepatitis B: This liver
infection is spread via bodily fluids such as blood, saliva or
semen. Thus, pregnant mothers can transmit it to their infants.
People engaged in unprotected sex and drug users who share needles
are also at risk.
"Hepatitis B can be acute, but it can also progress to a chronic condition,
meaning it lasts for longer than six months. Younger people who
contract hepatitis B are more likely to progress to the chronic
stage. Ninety percent of babies with acute hepatitis B progress to
the chronic stage but only two to five percent of adults move from
the acute to chronic stage," says Lok.
Because the disease frequently progresses to chronic infection, the CDC
recommends that the hepatitis B vaccine be given to all babies at
birth. For children and adolescents born before the implementation
of universal vaccination, catch-up vaccination is recommended.
Adults should consider the vaccine if they are at risk.
- Hepatitis B symptoms: During the acute stage: fever, fatigue, loss of
appetite, nausea, vomiting and jaundice.
- Diagnosis: Blood test
- People at risk: Health care workers, some law enforcement personnel, drug
users sharing needles, babies born to mothers already infected,
someone having unprotected sex with a hepatitis B-positive
partner, people from areas where hepatitis B is common, such as:
eastern Europe, southeast Asia, some African countries.
- How it spreads: Direct contact with bodily fluids, such as blood, semen
and saliva, for example, through unprotected sexual contact or
sharing of needles during drug use. It can also be spread from an
infected mother to a baby during childbirth.
-
Prevention: For people at risk: vaccination. Avoid exposure to
blood or bodily fluids. Do not share razors or toothbrushes. Use
safe sex practices utilizing barrier contraception (condoms).
- Treatment: There is no cure at this time. Some people carry the virus but
remain well. Two approved treatments are available for those with
chronic hepatitis B but not all patients respond to these
treatments, and long-term response is uncommon.
Hepatitis C: The virus for
hepatitis C is largely spread via a blood-to-blood contact. People
who have had a blood transfusion before 1990 (when effective blood
screening tests were developed) are at risk, as well as anyone
sharing needles.
"Unfortunately, despite very diligent work, we still haven't come up
with a vaccine for hepatitis C. That's one reason why so much
attention is paid to treating hepatitis C," says Lok.
- Hepatitis C symptoms: During acute hepatitis, there may be no symptoms, or
there could be fever, fatigue, loss of appetite, nausea, vomiting
and jaundice.
- Diagnosis: Blood test
- People at risk: Health care workers, some law enforcement personnel, drug
users sharing needles, people with transfusions before 1990 and
people with multiple sex partners. Some physicians recommend the
testing of babies born to hepatitis C mothers, as well as sex
partners of those carrying the infection.
- How it spreads: Blood-to-blood contact between two people
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Prevention: People with hepatitis C should not share razors or
toothbrushes. As a courtesy, notify any health care professionals
who may come into contact with the infected person's blood. There
is no vaccination against hepatitis C at this time.
- Treatment: Some people carry the virus but remain well. Current treatment is
associated with a sustained response in approximately 50 percent
of patients and should be considered in patients with chronic
hepatitis C and scarring (fibrosis) of the liver.
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