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Viral hepatitis: early detection can head off later complications

 

Hepatitis means 'inflammation of the liver.' Hepatitis may be caused by viruses, drugs and other causes. Hepatitis A, B and C are the most common forms of viral hepatitis. Viral hepatitis can be a potentially fatal disease, one that affects millions of Americans. But, hepatitis can be a 'silent killer,' in that hepatitis infection may produce no symptoms for years, even decades.

"During chronic infection, it is much more difficult to make a diagnosis. Chronic means lasting longer than six months. Most patients with chronic hepatitis B or C have no symptoms until they have very advanced liver damage, so they remain symptom free for up to decades. It's only when they start developing cirrhosis or liver cancer that they start manifesting symptoms," says Anna Lok, M.D., professor of internal medicine and director of clinical hepatology at the U-M Health System.

"On the other hand, hepatitis A is a transient, acute infection. It doesn't progress to chronic infection, so its impact on morbidity, mortality, as well as health care costs, is far less than with hepatitis B and C," she explains. "Most people recover from hepatitis A with supportive care only."

According to Lok, the Centers for Disease Prevention and Control estimates that about 3 million Americans are chronically infected with the hepatitis C virus, which is the most common hepatitis in the United States. Hepatitis C is also the most frequent reason for liver transplantation among adult patients. Roughly 1.25 million Americans have chronic hepatitis B.

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Lok warns that individuals should know of the risk factors for acquiring viral hepatitis and if they are concerned that they have any of those risk factors they should talk to their health care providers, and consider a simple blood test to determine if they are infected.

"It is so much easier to diagnose early and treat early. Treatment in an early stage, if successful, may prevent progression of the liver disease, and knowing you have it also allows you to take necessary steps to prevent transmission of the infection to others. People who already know they are hepatitis B or C positive should seek further evaluation even if they have no symptoms, because is very common for people to not have symptoms until the liver damage is very severe," says Lok.

Not all patients with chronic hepatitis B or C require specific medical treatment but some may benefit from active intervention. If you know that you are infected, see your physician to determine the severity of liver damage and if you may benefit from treatment.

It is important to note that alcohol accelerates the disease's progress in people with chronic hepatitis.

"In patients with cirrhosis, we recommend complete abstinence. Even small amounts of drinking can accelerate disease progression," Lok says.

Prevention is also an important tool for preventing the spread of these infections. There are specific preventions people can take to protect others, such as avoiding sharing needles or household articles (such as razors and toothbrushes) that may be contaminated with blood, and practicing safe sex. There are vaccines for hepatitis A and B. As hepatitis C is spread only through blood-to-blood contact, health care workers, law enforcement personnel and others at risk for exposure are trained in the precautions they can take.

Here are the facts:

Hepatitis A: This liver infection is largely spread through contaminated food or water. It causes acute infection only, meaning there is a single transient episode of the disease. The virus is harbored in the stools of people who are infected and can move to other people's food via unwashed hands. Problems with municipal sewage systems can also release infected sewage into the water supply.

The older an infected person is, the more likely the acute attack will be severe. Mortality is between two and three percent if the patient's age is over 50, but mortality is nearly zero for younger people. People can have it and not know it because the symptoms aren't always severe.

  • Hepatitis A symptoms: Fever, fatigue, loss of appetite, nausea, vomiting and jaundice.
  • Diagnosis: Blood test
  • People at risk: People traveling to underdeveloped countries; the military; those working in day care where there are a lot of incontinent babies in diapers
  • How it spreads: Usually spread by eating food or drinking water that has been contaminated by the virus. The virus can be found in the stools of people who have hepatitis A, so poor hand-washing techniques by someone infected with the virus, or sewage spills into the community water system are common ways for the virus to spread.
  • Prevention: For people at risk: vaccination. To minimize spread to food and water: good hand washing techniques among people with hepatitis A; enforcing sewage laws and keeping sewage treatment plants in good working condition
  • Treatment: Most people improve on their own, over a few weeks or months. Hepatitis A does not progress to chronic infection and will not cause cirrhosis.

Hepatitis B: This liver infection is spread via bodily fluids such as blood, saliva or semen. Thus, pregnant mothers can transmit it to their infants. People engaged in unprotected sex and drug users who share needles are also at risk.

"Hepatitis B can be acute, but it can also progress to a chronic condition, meaning it lasts for longer than six months. Younger people who contract hepatitis B are more likely to progress to the chronic stage. Ninety percent of babies with acute hepatitis B progress to the chronic stage but only two to five percent of adults move from the acute to chronic stage," says Lok.

Because the disease frequently progresses to chronic infection, the CDC recommends that the hepatitis B vaccine be given to all babies at birth. For children and adolescents born before the implementation of universal vaccination, catch-up vaccination is recommended. Adults should consider the vaccine if they are at risk.

  • Hepatitis B symptoms: During the acute stage: fever, fatigue, loss of appetite, nausea, vomiting and jaundice.
  • Diagnosis: Blood test
  • People at risk: Health care workers, some law enforcement personnel, drug users sharing needles, babies born to mothers already infected, someone having unprotected sex with a hepatitis B-positive partner, people from areas where hepatitis B is common, such as: eastern Europe, southeast Asia, some African countries.
  • How it spreads: Direct contact with bodily fluids, such as blood, semen and saliva, for example, through unprotected sexual contact or sharing of needles during drug use. It can also be spread from an infected mother to a baby during childbirth.
  • Prevention: For people at risk: vaccination. Avoid exposure to blood or bodily fluids. Do not share razors or toothbrushes. Use safe sex practices utilizing barrier contraception (condoms).
  • Treatment: There is no cure at this time. Some people carry the virus but remain well. Two approved treatments are available for those with chronic hepatitis B but not all patients respond to these treatments, and long-term response is uncommon.

Hepatitis C: The virus for hepatitis C is largely spread via a blood-to-blood contact. People who have had a blood transfusion before 1990 (when effective blood screening tests were developed) are at risk, as well as anyone sharing needles.

"Unfortunately, despite very diligent work, we still haven't come up with a vaccine for hepatitis C. That's one reason why so much attention is paid to treating hepatitis C," says Lok.

  • Hepatitis C symptoms: During acute hepatitis, there may be no symptoms, or there could be fever, fatigue, loss of appetite, nausea, vomiting and jaundice.
  • Diagnosis: Blood test
  • People at risk: Health care workers, some law enforcement personnel, drug users sharing needles, people with transfusions before 1990 and people with multiple sex partners. Some physicians recommend the testing of babies born to hepatitis C mothers, as well as sex partners of those carrying the infection.
  • How it spreads: Blood-to-blood contact between two people
  • Prevention: People with hepatitis C should not share razors or toothbrushes. As a courtesy, notify any health care professionals who may come into contact with the infected person's blood. There is no vaccination against hepatitis C at this time.
  • Treatment: Some people carry the virus but remain well. Current treatment is associated with a sustained response in approximately 50 percent of patients and should be considered in patients with chronic hepatitis C and scarring (fibrosis) of the liver.

 

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