olympics and drugs

low testosterone link with Alzheimer's disease

 

Wayne State University Professor Scott Moffat and his university colleagues have discovered a link between low testosterone and Alzheimer’s disease (AD) in older men. 

“This is a big step forward in helping to understand how sex hormones affect the aging body and brain,” said Moffat, the head investigator on the study, which appears in the Jan. 27, 2004 issue of the journal Neurology.

Moffat, an assistant professor with the University's Institute of Gerontology and department of psychology, conducted this study in collaboration with other research scientists at the National Institute on Aging (NIA), 1 of the National Institutes of Health, and WSU.

“We still have much to learn,” Moffat said. “For now, testosterone therapy should not be considered an option for older men seeking to reduce their risk of Alzheimer’s disease or to improve their memory.”

However, Moffat cautions that there is a lot more research needed before we can establish a causal relationship between low testosterone and AD.

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In this study, investigators evaluated the testosterone levels of 574 men, ages thirty-two to eighty-seven, who participated in the Baltimore Longitudinal Study of Aging (BLSA). They examined “total” and  “free” testosterone levels—measured over an average of nineteen years—in relationship to subsequent diagnosis of AD. Launched in 1958, the BLSA is USA's longest running scientific examination of human aging. Researchers there have measured testosterone levels in male participants since 1963.

The research team found that for every fifty percent increase in the free testosterone in the bloodstream, there was about a 26 percent decrease in the risk of developing AD. Although overall free testosterone levels dropped over time, these levels fell more dramatically in those men who later developed AD. In fact, at the end of the study, men who were diagnosed with AD, on average, had about 1/2 the levels of circulating free testosterone as men who didn’t develop the disease. In some cases, the drop-offs in free testosterone levels associated with AD were detected up to a 10 years before diagnosis.

“It’s quite possible that free testosterone has many different influences on the aging brain,” he suggests. “The effects of some of these influences—on certain types of memory loss and Alzheimer’s disease, for example—are just beginning to be explored.”

Other BLSA studies suggest that men older than seventy usually have lower levels of free testosterone than young men. But while prescription testosterone replacement therapy is available, it may not be advisable for most older men because the side effects of this hormone therapy are uncertain. It is not yet known, for instance, if testosterone replacement increases the risk of prostate cancer, the 2nd leading cause of cancer death among men. In addition, studies suggest that testosterone therapy might increase a man's risk of stroke. Carefully designed and monitored clinical trials will help to clarify the benefits and risks of testosterone therapy.

The controversy over drug use in athletics has also led to Senator John McCain offering help from a Legislative level. Major League Baseball and the International Olympic Committee are continuing investigations and seeking out possible reform to existing policies relating to the use of steroids and other drugs.

The toxicology report on Baltimore Orioles pitching prospect Steve Bechler released today implicates the use of the herbal supplement ephedra in his death, and underscores once more the dangers of ephedra use, particularly when combined with other risk factors.

The average layperson might think age 10 a bit of a stretch. But according to several drug-use experts at The University of Montana, ergogenics aren't just for college and professional athletes. Their use starts as early as middle school and is common among high school athletes.

Many physicians feel that some dietary supplements' should be considered drugs' because they contain known active ingredients, whereas dietary supplements' have little or no physiologic effects.

An athletic boost in the short term may mean health problems in the long term for teens who use performance-enhancing drugs, warns a youth sports medicine specialist from the University of Michigan Health System

Leading research scientists are saying  that the detection of EPO and HGH abuse is quite difficult because they appear only in very very small quantities in body fluids. EPO increases oxygen uptake to the working muscles, and HGH improves muscle growth.

USA Football has joined with a group of the nation's leading public health, medical and sports organizations to support legislation that relates to the regulation of dietary supplements that contain steroid precursors like ephedra.

"The benefits of higher testosterone levels have a down side, however," Booth notes. "Some, but not all, men with elevated levels of testosterone are more likely to engage in behavior that negates the beneficial effects of testosterone."

Steering young people away from using steroids is especially difficult not just because their sports idols may use them, but also because anabolic steroids are very easy for adolescents to get.

Parents don't have to sit helplessly by when they suspect -- or know -- their child is using a performance-enhancing drug. They should find out why their child is interested in using drugs and where the pressure is coming from. Is he or she getting wrong information from peers or from somebody at the gym?

Wadler, who is attending the ACSM Annual Meeting in St. Louis this week, said that the subject of steroid use in baseball peaked in 1998, when Mark McGwire admitted to the use of the testosterone precursor, androstenedione.

Proposed a warning label for all ephedra-containing dietary supplements. The proposed label warns about the risks of serious adverse events, including seizure, heart attack, stroke, and even death.

 

Recent studies suggest that steroid abuse among teenagers is on the rise. The study indicates that students at the 8th grade level (and even younger) are beginning to experiment with steroids with little understanding of their potential deadly side effects.

Scientists are increasingly concerned that sophisticated techniques for evading drug tests will make it difficult for testers to catch athletes using steroids and other drugs, especially at future athletic competitions when genetic-based enhancements are expected to be prevalent.

The Department of Health and Human Services (HHS) has made an announcement that a series of actions aimed at protecting US citizens from the potential grave risks associated with dietary supplements that contain ephedra.

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"We are not sure why women's testosterone elevation prior to competition is so much greater than it is in men. It is probably due to the fact that every day levels of testosterone are four times higher in men than they are in women.