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Heart disease risk and your lifestyle
 

A recently-published analysis from the Nurses' Health Study found that subjects in the low-risk-lifestyle group had only 17 percent of the risk to develop coronary artery disease as the other women in the study.

Every now and then, a scientific report comes along that emphasizes the association between lifestyle and health.  Subjects in the low-risk group were nonsmokers who ate a healthful diet and exercised at least 30 minutes per day.



The Nurses' Health Study

The Nurses' Health Study began in 1976, when 121,700 female nurses in the U.S., ages 30 to 55, agreed to serve as subjects. Every two years, these women complete questionnaires, and the researchers collect the data and look for relationships among the measured factors. In this recent study, the researchers examined the relationships between lifestyle factors and the risk of coronary heart disease and stroke.

Data from 84,129 women were analyzed over a 14-year period (1980 to 1994). The lifestyle factors that were most salient in predicting coronary events (fatal and nonfatal heart attacks) were: 1) smoking, 2) body mass index, 3) physical activity level, 4) dietary habits and 5) alcohol intake.

Smoking

Smoking status was the most salient lifestyle risk factor. Smoking increased coronary artery disease risk in a dose-response fashion: The greater the number of cigarettes smoked daily, the greater the risk. Even low levels of smoking increased risk. For example, women who smoked one to 14 cigarettes per day had three times the heart disease risk of nonsmokers. Women who smoked 15 or more cigarettes per day had more than five times the risk for heart disease.

Body mass index

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   Body mass index (BMI) is a pretty good estimate of obesity, on average. While some very muscular people will be counted as obese when they are actually very lean, the overall results will not be affected by this small error.

The standard cutoff for obesity is a BMI of 25, which was the number used in this study to define the low-risk lifestyle group. The researchers mention that in previous analyses, however, they calculated that even a BMI of 23 or 24 is riskier than a BMI of 21 or less. Research suggests that higher BMIs are associated with insulin resistance, which is associated with a riskier blood lipid profile.

Physical activity

The more minutes per day spent performing moderate to vigorous physical activity, the less the risk of heart disease. While the low-risk group was defined as exercising at a moderate to vigorous intensity for at least 30 minutes a day, the researchers acknowledged that more activity was better.

How did the researchers define physical activity? They counted activities that were approximately 3 METs or higher, which excludes normal walking, but includes walking at a pace equal to or greater than 3 miles per hour. The questionnaire asked about activities that were "strenuous enough to build up a sweat."

Dietary habits

The dietary habits included in the low-risk-profile group were chosen from previous research studies supporting their connection to cardiovascular risk reduction. Each subject's diet score was based on the following ingredients:

Fat intake. Subjects scored best if they had low intakes of trans fats and saturated fats, and higher intakes of unsaturated fats.

Fiber. Subjects who ate higher amounts of cereal fiber scored better. Cereal fiber is found in whole grains, brans and their products. Low-risk nurses consumed more than 4.2 grams of fiber per day.

Marine n-3 fatty acids. These fats come from fish and fish oils. The low-risk group consumed more than 0.1 percent of their daily calories in the form of these fats. So for a 2,000-Calorie diet, that is 2 Calories, or 18 grams, of marine n-3 fatty acids per day, on average. In real life, this translates into eating fish regularly.

Glycemic load. Glycemic load reflects both the glycemic index of foods (how long it takes the carbohydrate in the food to appear as glucose in the blood) and the volume of carbohydrate in the food. Higher glycemic load has been associated with increased heart disease risk, especially in overweight people. While no firm limit can be set for glycemic load at this point, the researchers emphasize the importance of consuming heart-healthy fats and protein along with nutritious carbohydrate foods, such as whole grains, legumes, fruits and vegetables, while limiting sugars and refined grains.

Folate. Higher folate intakes gave women more points on their diet classification. Low-risk women ate on the average more than 525 micrograms of folate per day, through supplements and foods combined. (Current recommended intake for folate is 400 micrograms per day for adult women and men.)

Alcohol intake

Women were considered low-risk if they consumed on average at least one-half of an alcoholic drink per day. Since alcohol intake is associated with an increased risk for breast cancer, many women avoid alcohol, but this study did not examine cancer risk. Small to moderate amounts of alcohol have been found to be protective against heart disease in both men and women.

The importance of lifestyle

Our healthcare system puts most of its heart disease money and energy into medical and surgical management: drugs to lower blood pressure and cholesterol, surgery to fix clogged arteries, etc. Research from the Nurses' Health Study, however, underscores the dramatic potential of lifestyle changes for the prevention of coronary artery disease.

REFERENCE

1. Stampfer, M.J., F.B. Hu, J.E. Manson, E.B. Rimm and W.C. Willett. Primary prevention of coronary heart disease in women through diet and lifestyle. The New England Journal of Medicine 343: 16-22, Jul. 6, 2000.

Barbara A. Brehm, Ed.D., is professor of exercise and sport studies at Smith College, Northampton, Mass.
 

 

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Instead of worrying about a food's glycemic index, keep an eye on portion sizes and consume carbohydrates with foods that are high in fiber and protein, and with moderate amounts of heart-healthy fats.